The Effect of Pulse Field Ablation on Atrial Mechanics Assessed by MRI and on Patient-related Outcomes in Catheter Ablation of Paroxysmal Atrial Fibrillation

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to compare the effect of pulmonary vein isolation on atrial function between pulse-field and cryoablation in patients over the age of 18 with paroxysmal atrial fibrillation. The main question it aims to answer is: • Is catheter ablation energy (pulse field ablation) revealing a better preservation of the atrial function architecture than with conventional catheter ablation technologies ? Participants will performed 2 IRMs with injection and completed Quality of Life Questionnaires. They participate in the study for 4 months. Researchers will compare 2 arms: * Pulse-Field Ablation * Cryoablation

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient age ≥ 18

• Established diagnosis of paroxysmal fibrillation, with a I/IIa/IIb indication for catheter ablation (ESC 2020 guidelines)

• Episode of AF documented by ECG within the last 12 months

• Patient able to give written informed consent

• If female of childbearing potential, have a negative serum pregnancy test and using effective contraception

• Be affiliated with a French social security system or entitled

Locations
Other Locations
France
Dr Mikael Laredo
RECRUITING
Paris
Contact Information
Primary
Mikael Laredo, MD, PhD
mikael.laredo@aphp.fr
+33184827620
Time Frame
Start Date: 2024-10-09
Estimated Completion Date: 2026-10-01
Participants
Target number of participants: 80
Treatments
Active_comparator: Pulmonary vein isolation by pulse field ablation
Active_comparator: Pulmonary vein isolation by cryoablation
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov